Download e-book for iPad: Aging at the Molecular Level by Nicolle Sitte, Thomas von Zglinicki (auth.), Thomas von
By Nicolle Sitte, Thomas von Zglinicki (auth.), Thomas von Zglinicki (eds.)
During the final forty years, the learn of the organic foundation of getting older has stepped forward vastly, and it has now turn into an autonomous and decent box of research and examine. the fundamental reason behind getting older is molecular harm that slowly overwhelms mobile and organismic safety, fix and upkeep structures. lately, a wealth of hugely subtle learn has remodeled this concept from a reputable speculation not just to a huge concept, yet primarily to approved wisdom. getting older on the Molecular point examines the most important parts during this transformation.
Bringing jointly contributions from a world workforce of authors, this quantity could be of curiosity to graduates and postgraduates within the fields of drugs and nursing, researchers of other points of biogerontology and people within the pharmaceutical, cosmeceutical, nutraceutical and health-care industry.
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Actin and neurofilaments) can interfere with their polymerization and leads to disruption of cytoskeletal elements [18, 19]. Generation of protein carbonyl derivatives Lysine, arginine, threonine, and proline residues of proteins are particularly sensitive to metal-catalyzed oxidation, leading in each case to the formation of carbonyl derivatives . As described above, peptide carbonyl compounds are also obtained as fragmentation products of peptide bond cleavage. In addition, carbonyl groups may be introduced into proteins by reactions with lipid peroxidation products (Figure 7)  (Michael addition) including 4-hydroxy-2-nonenal (HNE), 2-propeneal (acrolein)  or malondialdehyde [22, 23].
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Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage. Proc Nat! Acad Sci USA 96: 13300-5. 35. de Souza-Pinto NC, Eide L, Hogue BA, et al. (2001). -defective mice. Cancer Res. 61: 5378-81. 36. Le Page F, Kwoh EE, Avrutskaya A, et al. (2000b). Transcription-coupled repair of 8oxoguanine: requirement for XPG, TFIIH, and CSB and implications for Cockayne syndrome. Cel/101: 159-71. OXIDATIVE DNA DAMAGE AND REPAIR - IMPLICATIONS FOR AGING 25 37. Takao M, Kanno S, Kobayashi K, eta/.
Aging at the Molecular Level by Nicolle Sitte, Thomas von Zglinicki (auth.), Thomas von Zglinicki (eds.)