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By Perkin G David
Any dialogue of the medical features of Parkinson's sickness needs to have in mind the inaccuracies of medical prognosis. In a successive sequence of a hundred sufferers with a medical prognosis of Parkinson's affliction, simply seventy six fulfilled the factors for prognosis at autopsy exam. makes an attempt to tighten the diagnostic standards result in elevated specificity yet with lowered sensitivity.In An Atlas of Parkinson's disorder and similar problems Dr. David Perkin has compiled a chain of photos highlighting numerous features of Parkinson's sickness and comparable motor issues. The publication presents an invaluable pattern of medical, investigative (CT, MRI, and puppy) and pathological pictures with succinct descriptive textual content of the problems featured. nearly one-third of the fabric during this ebook is pathological, incorporating either macroscopic and microscopic sections. an extra area of the fabric is represented by way of imaging, mostly magnetic resonance imaging (MRI) and positron emission tomography (PET) scanning. the realm of circulation issues has been relatively fruitful for puppy scanning, which gives you, with the improvement of particular ligands for a number of the receptor websites, to extra extend realizing of the pathophysiological mechanisms of the circulate problems. Reflecting the top criteria scientific images and imaging in addition to the celebrated author's professional wisdom of the topic, Dr. Perkin's An Atlas of Parkinson's illness and comparable problems is the definitive and crucial medical reference in its box.
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Extra info for An Atlas of Parkinson's Disease and Related Disorders (Encyclopedia of Visual Medicine Series)
11C-raclopride is a selective reversible antagonist of D2 receptors) Figure 33 Coronal section of brain from a patient with striatonigral degeneration showing symmetrical atrophy and discoloration of the putamen ©2004 CRC Press LLC Figure 34 Histology of striatonigral degeneration shows atrophy of the putamen with rarefaction and gliosis (H & E) Figure 35 Transverse section of midbrain in striatonigral degeneration shows pallor of the substantia nigra ©2004 CRC Press LLC Figure 36 Axial (upper) and coronal (lower) T2-weighted MRIs showing putaminal hypointensity (arrowed) in a patient with striatonigral degeneration ©2004 CRC Press LLC Figure 37 Coronal sections showing normal (upper) compared with atrophied (lower) basis pontis secondary to olivopontocerebellar atrophy in multiple system atrophy Figure 38 Histological sections of basis pontis (arrowed) show the normal complement of pontine neurons in a control subject (left) compared with neuronal depletion (right) in multiple system atrophy (H & Es) ©2004 CRC Press LLC Figure 39 Multiple system atrophy with olivopontocerebellar atrophy.
Debris and a few vascular channels can be seen (Luxol fast blue–H & E) Figure 24 CT of a patient with a Parkinsonian syndrome shows multiple lacunar infarcts ©2004 CRC Press LLC Figure 25 T1-weighted MRI showing multiple small hypointense foci in the putamen and caudate nuclei bilaterally. The patient had presented with a Parkinsonian state with, eventually, predominant axial features Figure 26 Coronal brain section (same patient as in Figure 25) showing numerous small lacunes in the heads of both caudate nuclei and in the anterior part of the putamen ©2004 CRC Press LLC Figure 27 Histological sections from Parkinson's disease with dementia showing cortical Lewy bodies stained with ubiquitin (immunochemistry preparation, left; silver impregnation, right) Figure 28 Histology showing a subthalamic neuron containing a globose neurofibrillary tangle in progressive supranuclear palsy (Bielschowsky silver impregnation) ©2004 CRC Press LLC A B C D Figure 29 In this patient with progressive supranuclear palsy, upward (A) and lateral gaze (B and C) are preserved whereas down gaze (D) is impaired ©2004 CRC Press LLC Figure 30 Attempted down gaze (left) shows improvement with the doll's-head maneuver (right) in this patient with progressive supranuclear palsy Figure 31 Sagittal T1-weighted MRI showing midbrain atrophy (arrowed) in progressive supranuclear palsy ©2004 CRC Press LLC Figure 32 11C-raclopride binding in a normal subject (left) compared with that in Parkinson's disease (middle) and in progressive supranuclear palsy (right).
The leptomeninges have been partially removed to show cortical atrophy involving the posterior frontal and anterior parietal regions ©2004 CRC Press LLC Figure 45 Histological section of cerebral cortex in corticobasal degeneration shows severe gliosis and an achromatic neuron (H & E) Figure 46 Histological sections of cerebral cortex showing swollen cortical neurons in corticobasal degeneration with an appearance resembling chromatolysis (H & Es) ©2004 CRC Press LLC Figure 47 Histology of cerebral cortex in corticobasal degeneration shows a putaminal neuron (arrowed) containing a basophilic inclusion (H & E) Figure 48 Dorsal (left) and palmar (right) views of dystonic posturing of the left hand of a patient with corticobasal degeneration.
An Atlas of Parkinson's Disease and Related Disorders (Encyclopedia of Visual Medicine Series) by Perkin G David